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SPDP(SPDP Crosslinker)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SPDP(SPDP Crosslinker)图片
CAS NO:68181-17-9
规格:98%
分子量:312.36
包装与价格:
包装价格(元)
10mg询价
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SPDP是硫化氨的短链交联剂,能够通过NHS脂激活形成二硫键。
CAS:68181-17-9
分子式:C12H12N2O4S2
分子量:312.36
纯度:98%
存储:Store at -20°C

Background:

SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) were activated using SPDP .




[1]. Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104(11):4612-7. [2]. Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184(12):6695-708.


 
 
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