selective inhibitor of LPA2 activity
CAS：1017606-66-4
分子式：C20H23Cl2N5O2S2
分子量：500.46
纯度：98%
存储：Store at -20°C

Background:

LPA2 antagonist 1 is a LPA2 antagonist with an IC50 of 17 nM.

LPA2 antagonist 1 inhibits the phosphorylation of Erk induced by LPA in a concentration dependent manner. LPA2 antagonist 1 inhibits HCT-116 colon cancer cell proliferation caused by LPA in a doses dependent manner[1].

参考文献:
[1]. Beck HP, et al. Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1037-41.