Pancreatic Polypeptide,rat(Rat pancreatic polypeptide)

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	90419-12-8
规格:	98%
分子量:	4398.87

包装与价格：

包装	价格(元)
500ug	询价
1mg	询价
5mg	询价

PancreaticPolypeptide,rat是神经肽(NPY)受体激动剂，对NPYR4有很高的亲和性。
CAS：90419-12-8
分子式：C195H298N58O57S
分子量：4398.87
纯度：98%
存储：Store at -20°C

Background:

Pancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4.

Pancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic Polypeptide (1 μM) does not alter proliferation in BRIN BD11 or 1.1B4 beta-cells, but reverses the decreased cell viability in BRIN BD11 cells induced by streptozotocin. Pancreatic Polypeptide (0.1 nM-1 μM) shows no effect on insulin secretion from isolated mouse islets, and does not affect the membrane potential and (Ca2+)i levels in BRIN BD11 cells at 1 μM[1].

Pancreatic Polypeptide (25 nmol/kg bw, i.p.) reduces glucose-stimulated insulin concentrations but shows no effect on acute feeding behaviour in overnight fasted mice[1].

[1]. Khan D, et al. Influence of neuropeptide Y and pancreatic polypeptide on islet function and beta-cell survival. Biochim Biophys Acta. 2017 Apr;1861(4):749-758.