Sodium Channel inhibitor 1

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CAS NO:	1198117-23-5
规格:	98%
分子量:	473.42

Sodium Channel inhibitor1是新型的选择性电压门控钠离子通道，可用于疼痛治疗。
CAS：1198117-23-5
分子式：C24H19F4N3O3
分子量：473.42
纯度：98%
存储：Store at -20°C

Background:

Sodium Channel inhibitor1, one of 3-Oxoisoindoline-1-carboxamides, is a novel and selective voltage-gated sodium channel for pain treatment. IC50 Value: 0.16 uM ( Na v1.7, V hold-90mV); 0.41 uM (Na v1.7, V hold-90mV) [1]Target: Na v1.7Sodium Channel inhibitor1 demonstrated concentration-dependent efficacy in preclinical behavioral pain models.

[1]. Macsari I, et al. 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na(V)1.7with efficacy in rat pain models. J Med Chem. 2012 Aug 9;55(15):6866-80.