Neuromedin N 是大鼠多巴胺 D2 受体激动剂结合新纹状体膜的有效调节剂。
CAS：92169-45-4
分子式：C38H63N7O8
分子量：745.95
纯度：98%
存储：Store at -20°C

Background:

Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes. Dopamine D2 receptor[1].

Neuromedin N competitively inhibits the binding of neurotensin to rat brain synaptic membranes with a 19-fold lower potency than neurotensin and is rapidly inactivated by brain synaptic peptidases[1]. It competitively inhibits neurotensin binding to rat brain synaptic membranes and has increased potency in the presence of the peptidase inhibitor bestatin[2].

[1]. Li XM, et al. Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes. Neurosci Lett. 1993 Jun 11;155(2):121-4. [2]. Checler F, et al. Neuromedin N: high affinity interaction with brain neurotensin receptors and rapid inactivation by brain synaptic peptidases. Eur J Pharmacol. 1986 Jul 31;126(3):239-44.