2R,4R-Sacubitril是Sacubitri的杂质。美国食品和药物管理局批准Sacubitril与缬沙坦联合用于治疗患有心力衰竭的患者。
CAS：766480-48-2
分子式：C24H29NO5
分子量：411.49
纯度：98%
存储：Store at -20°C

Background:

2R,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and Drug Administration for use in combination with valsartan for the treatment of patients with heart failure.

[1]. Shi J, et al. Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation. Drug Metab Dispos. 2016 Apr;44(4):554-9.