Nav1.7-IN-2是电压门控钠通道抑制剂,尤其是Nav1.7,IC50值为80nM。
CAS：1332295-35-8
分子式：C22H22FN5O2
分子量：407.44
纯度：98%
存储：Store at -20°C

Background:

Nav1.7-IN-2 is an inhibitor of voltage-gated sodium channels (Nav), in particular Nav 1.7, with IC50 of 80 nM.IC50 value: 80 nMTarget: Nav 1.7Nav1.7-IN-2 is useful for the treatment of diseases treatable by inhibition of these channels, in particular, chronic pain disorder. The more detailed information please refer to WO 2011103196 A1. Nav1.7-IN-2 is a Nav1.7 channel inhibitor extracted from patent WO/2011103196 A1, compound example J, has an IC50 of 80 nM.

[1]. Bregman Howard, et al. Preparation of aryl carboxamide derivatives as sodium channel inhibitors for treatment of pain. From PCT Int. Appl. (2011), WO 2011103196 A1 20110825.