Endothelin1(swine,human)是具有人和猪内皮素1序列的合成肽，是有效的内源性血管收缩剂。Endothelin1通过两种类型受体ETA和ETB发挥作用。
CAS：117399-94-7
分子式：C109H159N25O32S5
分子量：2491.9
纯度：98%
存储：Store at -20°C

Background:

Endothelin 1 (swine, human) is a synthetic peptide with the sequence of human and swine Endothelin 1, which is a potent endogenous vasoconstrictor. Endothelin 1 acts through two types of receptors ETA and ETB.

Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. It acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion[1].

[1]. Kowalczyk A, et al. The role of endothelin-1 and endothelin receptor antagonists in inflammatory response andsepsis. Arch Immunol Ther Exp (Warsz). 2015 Feb;63(1):41-52.