HA-1004 is an inhibitor of protein kinase G (PKG) and PKA (Kis = 1.4 and 2.3 μM, respectively).
CAS：92564-08-4
分子式：C12H15N5O2S.2HCl
分子量：366.3
纯度：98%
存储：Store at -20°C

Background:

HA-1004 is an inhibitor of protein kinase G (PKG) and PKA (Kis = 1.4 and 2.3 µM, respectively). It also inhibits PKC and blocks intracellular calcium mobilization. HA-1004 induces relaxation of isolated rabbit aortic strips precontracted with histamine, serotonin , A23187 , angiotensin II , or prostaglandin F2α , as well as phenylephrine with or without calcium (EC50s = 2.3 and 0.5 µM, respectively). It also inhibits histamine-induced bronchoconstriction in guinea pigs without affecting blood pressure when administered intratracheally at a dose of 0.1 mg per animal.