DesethylKBT-3022是新型抗血小板药物KBT-3022的主要活性代谢物。
CAS：101001-72-3
分子式：C23H20N2O4S
分子量：420.48
纯度：98%
存储：Store at -20°C

Background:

Desethyl KBT-3022 is the main active metabolite of the new antiplatelet agent, KBT-3022.

Pretreatment with desethyl KBT-3022 0.1, 0.3 and 1 mg/kg, i.v. prolongs the time required to achieve thrombotic occlusion in the femoral artery and inhibits collagen-induced platelet aggregation in whole blood ex vivo, each in a dose-dependent manner. Desethyl KBT-3022 inhibits the thrombin-induced aggregation of washed platelets in a concentration-dependent manner 1-40 μM[1].

[1]. Shimazawa M, et al. Antithrombotic effects in a rat model of aspirin-insensitive arterial thrombosis of desethyl KBT-3022, the main active metabolite of a new antiplatelet agent, KBT-3022. Eur J Pharmacol. 1997 Jun 11;328(2-3):183-9.