25-Hydroxycholesterol是胆固醇的代谢产物，由巨噬细胞响应Toll样受体(TLR)激活而产生和分泌。25-Hydroxycholesterol有效且选择性抑制B细胞产生IgA，EC50约为65nM。
CAS：2140-46-7
分子式：C27H46O2
分子量：402.65
纯度：98%
存储：Store at -20°C

Background:

25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.

The synthesis of 25-hydroxycholesterol is catalyzed by the enzyme cholesterol 25-hydroxylase, which uses cholesterol and molecular oxygen as substrates and NADPH as a cofactor. 25-hydroxycholesterol is a potent bioactive lipid in the innate and adaptive immune systems[1].

[1]. McDonald JG, et al. Editorial: 25-Hydroxycholesterol: a new life in immunology. J Leukoc Biol. 2010 Dec;88(6):1071-2.