4-Phenoxybenzylamine通过稳定无活性构象来抑制NS3蛋白的功能，抑制FLNS3/4a的IC50值约为500μM。
CAS：107622-80-0
分子式：C13H13NO
分子量：199.25
纯度：98%
存储：Store at -20°C

Background:

4-Phenoxybenzylamine inhibits the function of the NS3 protein by stabilizing an inactive conformation with an IC50 of about 500 μM against FL NS3/4a.

A highly conserved novel binding site located at the interface between the protease and helicase domains of the Hepatitis C Virus (HCV) NS3 protein is identified. 4-Phenoxybenzylamine binding at this allosteric site inhibits the function of the NS3 protein by stabilizing an inactive conformation and thus represents a new class of direct acting antiviral agents[1].

[1]. Saalau-Bethell SM, et al. Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function. Nat Chem Biol. 2012 Nov;8(11):920-5.