TC-I2014(compound5)是一种强效的、苯并咪唑类的、TRPM8的拮抗剂，其对犬类、人和大鼠通道的IC50值分别为0.8nM,3.0nM和4.4nM。在疼痛动物模型中具有抗痛觉超敏作用。
CAS：1221349-53-6
分子式：C23H19F6N3O
分子量：467.41
纯度：98%
存储：Store at -20°C
Background:
TC-I 2014 (compound 5) is a potent Benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonist, with IC50 values of 0.8 nM, 3.0 nM and 4.4 nM for canine, human and rat channels respectively. TC-I 2014 exhibits antiallodynic properties in pain models[1].
TRPM8[1].
[1]. Parks DJ, et Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists. J Med Chem. 2011 Jan 13;54(1):233-47.
