ICA(N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine)

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CAS NO:	3374-88-7
规格:	98%
分子量:	254.31

包装与价格：

包装	价格(元)
1mg	询价
5mg	询价
10mg	询价
50mg	询价

ICA(N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine)是SK通道(SKchannel)抑制剂。ICA有抗利什曼原虫活性，IC50值为2.1μM。
CAS：3374-88-7
分子式：C13H10N4S
分子量：254.31
纯度：98%
存储：Store at -20°C

Background:

ICA (N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC50 of 2.1 µM.

The SK channel inhibitor ICA exhibits antiarrhythmic effects. ICA prevents electrically induced runs of atrial fibrillation in the isolated right atrium and induces atrial postrepolarization refractoriness and depolarizes resting membrane potential. ICA at 1 to 10 μM slows conduction velocity. At increased pacing frequencies, SK channel inhibition by ICA (10-30 μM) demonstrates prominent depression of other sodium channel-dependent parameters[2].

[1]. Bhuniya D, et al. Aminothiazoles: Hit to lead development to identify antileishmanial agents. Eur J Med Chem. 2015 Sep 18;102:582-93. [2]. Skibsbye L, et al. Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium. J Cardiovasc Pharmacol. 2015 Aug;66(2):165-76.