Inactive derivative of KN-93,control compound
CAS：1431698-47-3
分子式：C24H26Cl2N2O3S
分子量：493.45
纯度：98%
存储：Store at -20°C

Background:

KN-92 is an inactive analog of KN-93. KN-93 is the CaM kinase II inhibitor. [1]

Hearts were treated with the CaM kinase inhibitor KN-93 or the inactive analog KN-92 (0.5 μM) for 10 min before clofilium exposure. Early afterdepolarizations?(EADs) were largely inhibited by KN-93 contrasted to KN-92. There were little differences in parameters favoring EADs such as monophasic action potential duration or heart rate in KN-92- or KN-93- treated hearts. CaM kinase activity?in situ increased 37% in hearts with EADs compared to hearts without EADs. This increase in CaM kinase activity was prevented by pretreatment with KN-93.?[1]

In vitro, KN-93 potently suppressed rabbit myocardial CaM kinase activity (calculated Ki?≤ 2.58 μM), but the inactive analog KN-92 did not (Ki?>100 μM). The actions of KN-93 and KN-92 on ICa?and other repolarizing K+currents did not illustrate preferential EAD suppression by KN-93. [1]

Reference:
1.  KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J Pharmacol Exp Ther. 1998 Dec;287(3):996-1006.