Selitrectinib(LOXO-195)

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CAS NO:	2097002-61-2
规格:	98%
分子量:	380.42

包装与价格：

包装	价格(元)
1mg	询价
5mg	询价
10mg	询价
25mg	询价
50mg	询价
100mg	询价

Selitrectinib(LOXO-195)是原肌凝蛋白相关激酶(TRK)的一个二代抑制剂，其对TRKA和TRKC的IC50值分别为0.6nM和<2.5nM。
CAS：2097002-61-2
分子式：C20H21FN6O
分子量：380.42
纯度：98%
存储：Store at -20°C

Background:

Selitrectinib (LOXO-195) is a next-generation TRK kinase inhibitor (TKI), with IC50s of 0.6 nM,<2.5 nM for TRKA and TRKC respectively.

Selitrectinib (LOXO-195) demonstrates strong binding to the wild-type TRKA, TRKB and TRKC kinase domains. Selitrectinib (LOXO-195) has potent (IC50<1 nM) inhibitory activity in kinase enzyme assays. Importantly, Selitrectinib (LOXO-195) achieves low nanomolar inhibitory activity against TRKA G595R, TRKC G623R, and TRKA G667C, with IC50s ranging from 2.0-9.8 nM. 228 individual kinases in vitro are profiled at a Selitrectinib (LOXO-195) concentration of 1 μM, which is