HUHS015在体内体外都是PCA-1/ALKBH3强有力的抑制剂，持续的注射HUHS015能够显著的抑制DU145细胞的生长。
CAS：1453097-13-6
分子式：C19H18N4O
分子量：318.37
纯度：98%
存储：Store at -20°C

Background:

HUHS015 is a potent PCA-1/ALKBH3 inhibitor both in vitro and in vivo. The bioavailability (BA) of HUHS015 was 7.2% in rats after oral administration. Continuously administering HUHS015 significantly suppressed the growth of DU145 cells, which are human hormone-independent prostate cancer cells, in a mouse xenograft model without untoward effects. [1]

[1]. Nakao S et al. Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs. Bioorg Med Chem Lett, 2014 Feb 15, 24(4):1071-4.