PGS-IN-1是有效的前列腺素合成酶(prostaglandinsynthetase)抑制剂，IC50值为0.28μM；也可抑制5-脂肪氧合酶(5-lipoxygenase)的活性，IC50值为1.05μM。
CAS：102271-49-8
分子式：C19H26O3
分子量：302.41
纯度：98%
存储：Store at -20°C

Background:

PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS) with an IC50 of 0.28 μM; also inhibits 5-lipoxygenase with an IC50 of 1.05 μM.

The synthesized α-benzulidene-γ-butyrolactones are pure isomers (either cis or trans). PGS-IN-1 is the trans isomer. PGS-IN-1 exhibits potent antiinflammatrory and PGS inhibitory activity (IC50=0.28 μM). PGS-IN-1 also shows potent inhibitory activity against 5-lipoxygenase (IC50=1.05 μM)[1].

[1]. Katsumi I, et al. Studies on styrene derivatives. I. Synthesis and antiinflammatory activities of alpha-benzylidene-gamma-butyrolactone derivatives. Chem Pharm Bull (Tokyo). 1986 Jan;34(1):121-9.