KY-556是一种针对过敏性疾病的具有口服活性的色甘酸二钠(DSCG)的前药。
CAS：110816-78-9
分子式：C33H38Cl2N2O12
分子量：725.57
纯度：98%
存储：Store at -20°C

Background:

KY-556 is a promising and orally-active pro-drug of disodium cromoglycate (DSCG) against allergic diseases.

The oral anti-allergic effect of KY-556 (N-556) is investigated. N-556 (10-100 mg/kg, p.o.) inhibits dose-dependently the 48-hr homologous passive cutaneous anaphylaxis (PCA) in rats, and the duration of action is longer than that of intravenous Disodium cromoglycate (DSCG). N-556 (20 and 100 mg/kg once a day for 20 consecutive days, p.o.) tends to inhibit the histamine release from actively sensitized rat lung fragments. N-556 (100 mg/kg, p.o.) shows the prolongation of survival time in the rat systemic anaphylaxis. N-556 (100 mg/kg, p.o.) significantly inhibits the increased airway resistance in experimental asthma in rats[1].

[1]. Nakamura S, et al. Effects of N-556 on experimental allergy models in rats. Arerugi. 1990 Dec;39(12):1621-8.