Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 μM..
CAS：1020412-97-8
分子式：C31H35N3O5
分子量：529.6
纯度：98%
存储：Store at -20°C

Background:

Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 µM.. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 µM. This compound can prevent endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization.