8-Hydroxyguanine是由活性氧物质产生的主要诱变前损伤。 它导致G-T和A-C置换。
CAS：5614-64-2
分子式：C5H5N5O2
分子量：167.13
纯度：98%
存储：Store at -20°C

Background:

8-Hydroxyguanine is a major pre-mutagenic lesion generated from reactive oxygen species. It causes G-T and A-C substitutions. Human Endogenous Metabolite

[1]. Arai T, et al. High accumulation of oxidative DNA damage, 8-hydroxyguanine, in Mmh/Ogg1 deficient mice by chronic oxidative stress. Carcinogenesis. 2002 Dec;23(12):2005-10. [2]. Floyd RA, et al. The role of 8-hydroxyguanine in carcinogenesis. Carcinogenesis. 1990 Sep;11(9):1447-50. [3]. Cheng KC, et al. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions. J Biol Chem. 1992 Jan 5;267(1):166-72.