TAS4464 是一种高效选择性的 NEDD8 活化酶 (NAE) 抑制剂，IC50 值为 0.955 nM。
CAS：1848959-10-3
分子式：C21H23FN6O6S
分子量：506.51
纯度：98%
存储：Store at -20°C

Background:

TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM[1]. IC50:0.955 nM (NAE)[1]

TAS4464 treatment inhibits cullin neddylation and subsequently induces the accumulation of CRL substrates such as CDT1, p27, and phosphorylates IκBα in 47 human cancer cell lines.

[1]. Yoshimura C, et al. TAS4464, a highly potent and selective inhibitor of NEDD8 activating enzyme, suppresses neddylation and shows antitumor activity in diverse cancer models. Mol Cancer Ther. 2019 May 15.