Bis-PEG2-acid 是一种 PROTAC linker，属于 PEG 类。Bis-PEG1-propionic acid 可用于合成一系列 PROTAC 分子。
货号:ajcx29188
CAS:19364-66-0
分子式:C8H14O6
分子量：206.19
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Bis-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Zhao Q, et al. Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J Med Chem. 2019 Oct 24;62(20):9281-9298.