Gymnemic acid I 是一种在 Gymnema sylvestre 中发现的具有生物活性的三萜皂苷。
货号:ajcx19898
CAS:122168-40-5
分子式:C43H66O14
分子量：807
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Gymnemic acid I is a triterpene glycoside that has been found in G. sylvestre and has antihyperglycemic activities.1,2 It inhibits glucose-induced phosphorylation of serine 70 on S6 kinase (S6K1) and serine 2448 on mTOR, caspase-3 activity, and apoptosis, as well as increases autophagy in MIN-6 pancreatic β cells when used at a concentration of 5 μg/ml.1 Gymnemic acid I has been used as a reference compound to compare the potency of plant-derived sweet taste inhibitors.2

|1. Wu, Y., Hu, Y., Yuan, Y., et al. Gymnemic acid I triggers mechanistic target of rapamycin-mediated β cells cytoprotection through the promotion of autophagy under high glucose stress. J. Cell. Physiol. 234(6), 9370-9377 (2019).