ABC99 是一种 N-羟基乙内酰脲 (NHH) 氨基甲酸酯，可选择性抑制 Wnt 脱酰酶 NOTUM (IC50=13 nM)。 ABC99 在 NOTUM 存在的情况下保留 Wnt3A 信号。
货号:ajcx18022
CAS:2331255-53-7
分子式:C22H21ClN4O5
分子量：456.9
溶解度:1mg/mL in Chloroform, 1mg/mL in acetonitrile, 1mg/mL in methyl acetate
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ABC99 is an N-hydroxyhydantoin (NHH) carbamate that inhibits the Wnt-deacylating enzyme NOTUM (IC50 = 13 nM).[1] It preserves Wnt3A signaling in the presence of NOTUM (EC50 = 89 nM in a cell-based reporter assay).

参考文献:
[1]. Suciu, R.M., Cognetta, A.B., III., Potter, Z.E., et al. Selective irreversible inhibitors of the Wnt-deacylating enzyme NOTUM developed by activity-based protein profiling. ACS Med. Chem. Lett. 9(6), 563-568 (2018).