PROTAC(H-PGDS)-7 是一种造血前列腺素 D 合酶 (H-PGDS) PROTAC 降解剂，DC50 为 17.3 pM。
货号:ajcx26386
CAS:N/A
分子式:C40H38N8O7
分子量：742.8
溶解度:DMSO: 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PROTAC(H-PGDS)-7 is a proteolysis-targeting chimera (PROTAC) comprised of the hematopoietic prostaglandin D synthase (H-PGDS) inhibitor TFC-007 and the cereblon inhibitor pomalidomide .¹It induces degradation of H-PGDS in KU812 cells with a 50% degradation concentration (DC₅₀) value of 17.3 pM, as well as decreases the production of prostaglandin D₂(PGD₂) in the same cells.

1.Yokoo, H., Shibata, N., Endo, A., et al.Discovery of a highly potent and selective degrader targeting hematopoietic prostaglandin D synthase via in silico designJ. Med. Chem.64(21)15868-15882(2021)