Stephacidin B 是一种真菌代谢物。 Stephacidin B 对一组人类肿瘤细胞系显示出体外细胞毒性。 Stephacidin B 对睾酮依赖性前列腺 LNCaP 癌细胞具有最强的细胞毒性。
货号:ajcx23882
CAS:360765-75-9
分子式:C52H54N6O8
分子量：891
溶解度:
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Stephacidin B is a fungal metabolite that has been found inA. ochraceus.¹Dimeric stephacidin B is rapidly converted to a monomer, avrainvillamide ,in vitro.²Stephacidin B is cytotoxic to a variety of cancer cells, including testosterone-independent PC3 and -sensitive LNCaP prostate cancer cells (IC₅₀s = 0.37 and 0.06 µM, respectively) and estradiol-independent SK-BR-3 and -sensitive MCF-7 breast cancer cells (IC₅₀s = 0.32 and 0.27 µM, respectively).¹It induces apoptosis in HepG2 and Huh7 hepatocellular carcinoma cells when used at a concentration of 4 µM.³

1.Qian-Cutrone, J., Huang, S., Shu, Y.-Z., et al.Stephacidin A and B: Two structurally novel, selective inhibitors of the testosterone-dependent prostate LNCaP cellsJ. Am. Chem. Soc.124(49)14556-14557(2002) 2.Wulff, J.E., Herzon, S.B., Siegrist, R., et al.Evidence for the rapid conversion of stephacidin B into the electrophilic monomer avrainvillamide in cell cultureJ. Am. Chem. Soc.129(16)4898-4899(2007) 3.Hu, L., Zhang, T., Liu, D., et al.Notoamide-type alkaloid induced apoptosis and autophagy via a P38/JNK signaling pathway in hepatocellular carcinoma cellsRSC Adv.9(34)19855-19868(2019)