Cyclic MKEY TFA 是 CXCL4-CCL5 异二聚体形成的合成环肽抑制剂，其通过介导炎症来防止动脉粥样硬化和主动脉瘤形成。Cyclic MKEY TFA 还可以预防小鼠中风引起的脑损伤。
货号:ajcx13826
CAS:N/A
分子式:CC115H175N28F3O36S2
分子量：2646.91
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Cyclic MKEY TFA is a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, which protects against atherosclerosis and aortic aneurysm formation by mediating inflammation. Cyclic MKEY TFA also protects against stroke-induced brain injury in mice[1][2]. CXCL4-CCL5[1]

[1]. Fan Y,et al. MKEY, a Peptide Inhibitor of CXCL4-CCL5 Heterodimer Formation, Protects Against Stroke in Mice. J Am Heart Assoc. 2016 Sep 15;5(9). pii: e003615. [2]. Iida Y, et al. Peptide inhibitor of CXCL4-CCL5 heterodimer formation, MKEY, inhibits experimental aortic aneurysm initiation and progression. Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):718-26.