Antagonist of the androgen receptor in rats
货号:ajcx23734
CAS:83792-61-4
分子式:C11H11Cl2NO2
分子量：260.1
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2)(1:1): .5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Vinclozolin is a dicarboximide fungicide widely used in Europe and the United States for control of diseases caused byB. cinerea,S. sclerotiorum, andMoniliniaspecies in grapes, fruits, vegetables, ornamental plants, and turfgrass.¹Metabolites of vinclozolin, M₁and M₂, are effective antagonists of the androgen receptor in rats exhibiting K_ivalues of 92 and 9.7 µM respectively.²In fathead minnow, M₁and M₂failed to compete for high-affinity, low capacity testosterone binding sites in brain and ovary cytosolic fractions suggesting that they are not anti-androgens in this species.³

1.Pothuluri, J.V., Freeman, J.P., Heinze, T.M., et al.Biotransformation of vinclozolin by the fungus Cunninghemella elegansJ. Agric. Food Chem.48(12)6138-6148(2000) 2.Kelce, W.R., Monosson, E., Gamcsik, M.P., et al.Enviromental hormone disruptors: Evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolitesToxicol. Appl. Pharmacol.126(2)276-285(1994) 3.Makynen, E.A., Kahl, M.D., Jensen, K.M., et al.Effects of the mammalian antiandrogen vinclozolin on development and reproduction of the fathead minnowAquatic Toxicology48461-475(2000)