甲萘威主要用作杀虫剂。
货号:ajcx21996
CAS:63-25-2
分子式:C12H11NO2
分子量：201.2
溶解度:Chloroform: Slightly Soluble,Methanol: Slightly Soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Carbaryl is a carbamate insecticide that inhibits acetylcholinesterase (AChE; IC₅₀= 13.6 nM forA. gambiaeAChE2 expressed in Sf9 cells; K_i= 5.7 &#181M for rat brain AChE).^1,2Carbaryl administered at a dose of 30 mg/kg for 28 days in rats decreases the weight of spleen and thymus, proliferation of lymphocytes, and serum levels of IL-2, IFN-γ, IL-1β, and TNF-α, and increases the serum levels of IL-4 and IL-10.³It increases CaMKII, GAP-43, and tau protein levels in the hippocampus and tau levels in the cortex of mice 24 hours after administration of doses ranging from 0.5 to 20 mg/kg on postnatal day ten, whereas tau protein levels are decreased four months after administration with no change in CaMKII or GAP-43 compared with control mice. These effects occur at non-toxic doses where acetylcholinesterase is inhibited only during the first six hours following treatment. Formulations containing carbaryl have been used to control insects in agriculture.

1.Zhao, P., Wang, Y., and Jiang, H.Biochemical properties, expression profiles, and tissue localization of orthologous acetylcholinesterase-2 in the mosquito, Anopheles gambiaeInsect. Biochem. Mol. Biol.43(3)260-271(2013) 2.Hassan, A., Abdel-Hamid, F.M., and Bahig, M.R.E.Kinetics of inhibition of rat brain acetylcholinesterase by SevinZ. Naturforsch. B.22(5)505-507(1967) 3.Jorsaraei, S.G., Maliji, G., Azadmehr, A., et al.Immunotoxicity effects of carbaryl in vivo and in vitroEnviron. Toxicol. Pharmacol.38(3)838-844(2014)