LY-3381916是一种有效、选择性、可透过血脑屏障的IDO1抑制剂，能够与缺乏血红素的apo-IDO1结合，但无法与结合有成熟血红素的IDO1结合。
货号:ajcx12968
CAS:2166616-75-5
分子式:C23H25FN2O3
分子量：396.45
溶解度:DMSO: 300 mg/mL (756.72 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

LY-3381916 is a potent, selective and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1[1].

LY-3381916 (up to 100 µM) shows no obvious agonism of aryl hydrocarbon receptor (AHR)[1].

[1]. Frank C. Dorsey, et al. Abstract 5245: Identification and characterization of the IDO1 inhibitor LY3381916. Cancer Research. 2018, 78(13).