MARK-IN-1是一种有效的微管亲和力调节激酶(MARK)抑制剂，IC50<0.25nM。
货号:ajcx12508
CAS:1109283-93-3
分子式:C22H23F2N7OS
分子量：471.53
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of<0.25 nM.

MARK-IN-1 (Compound 25) is a potent MARK inhibitor. Inhibition of MARK represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer's disease[1].

[1]. Sloman DL, et al. Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4362-6.