A β-carboline alkaloid and an active metabolite of harmaline
货号:ajcx26628
CAS:6028-00-8
分子式:C12H12N2O • HCl [2H2O]
分子量：272.7
溶解度:DMF: 10 mg/ml,DMSO: 1 mg/ml,Ethanol: 2 mg/ml,PBS (pH 7.2): insol
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Harmalol is a β-carboline alkaloid and an active metabolite of harmaline that has been found inP. harmalaand has diverse biological activities.^1,2,3,4,5It is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A; IC₅₀= 0.63 µM) and monoamine oxidase A (MAO-A; IC₅₀= 0.66 µM).³It is selective for DYRK1A over Cdk1, Cdk5, CK1α1, Clk4, DYRK2, Pim-1, and GSK3β but also inhibits DYRK1B and Clk1 at 10 µM. It inhibits proliferation of H4 human glioblastoma cells (IC₅₀s = 23.7 µM). Harmalol (0.5-12.5 µM) reduces increases in the levels of the cytochrome P450 (CYP) isoform CYP1A1 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells and prevents TCDD-induced activation of the aryl hydrocarbon receptor (AhR) in guinea pig hepatic cytosolic extracts.⁴It reduces glutamate-induced cytotoxicity, cytochromecrelease, caspase-3 activation, and the production of reactive oxygen species (ROS) in PC12 cells when used at a concentration of 25 µM.⁵This product is also available as an analytical reference standard .

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