RMM 46 是一种选择性和可逆的 MSK/RSK 家族激酶共价抑制剂。
货号:ajcx27294
CAS:1307896-46-3
分子式:C24H26N4O5
分子量：450.5
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

MSK/RSK family kinase inhibitor. Exhibits selectivity for RSK2 over NEK2 and PLK1 (IC50s are 12, 530 and 2200 nM, respectively). Inhibits MSK1, MSK2, RSK2 and RSK3 in cellular assays. Reduces CREB phosphorylation in HeLa cells.

Miller et al (2013) Electrophilic fragment-based design of reversible covalent kinase inhibitors. J.Am.Chem.Soc. 135 5298 PMID:23540679