TLR-4 inhibitor
货号:ajcx27192
CAS:613263-00-6
分子式:C13H11N3OS.2HCl
分子量：330.23
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

TLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC50 = 2.4 μg/mL). Also inhibits LPS-induced cytokine production and procoagulant effects in PBMCs and HUVECs. Prolongs survival in a mouse septic shock model.

Nakamura et al (2007) Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice. Eur.J.Pharmacol. 569 237 PMID:17588563