Mps BAY 2a 是一种单极纺锤体 1 (MPS1) 抑制剂，对人 MPS1 的 IC50 为 1 nM。 Mps BAY 2a 在癌细胞中诱导有丝分裂畸变和凋亡。
货号:ajcx27120
CAS:1382477-96-4
分子式:C29H28N6O
分子量：476.57
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent and selective Mps1 inhibitor (IC50 = 1 nM for human enzyme). Selective for Mps1 over a panel of 220 kinases. Differentially inhibits human colon carcinoma cell proliferation. Blocks cell cycle progression by preventing spindle assembly checkpoint activation. Induces apoptosis.

Jemaà et al (2013) Characterization of novel MPS1 inhibitors with preclinical anticancer activity. Cell Death Differ. 20 1532 PMID:23933817