Potent and selective heme oxygenase 1 (HO-1) inhibitor
货号:ajcx27392
CAS:939825-12-4
分子式:C15H17BrN2O2.HCl
分子量：373.67
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent and selective heme oxygenase 1 (HO-1) inhibitor (IC50 values are 1.9 and >100 μM for HO-1 and HO-2 respectively), reduces protein carbonylation and reactive oxygen species formation in advanced prostate cancer cells (PCA). Inhibits cell proliferation in vitro and PCA tumor growth and lymph node/lung metastases in vivo. Synergizes with Taxol .

Alaoui-Jamali et al (2009) A novel experimental heme oxygenase-1-targeted therapy for hormone-refractory prostate cancer. Cancer Res. 69 8017 PMID:19808972