Danicamtiv，一种肌力剂，是心脏肌动蛋白 (cardiac myosin) 的选择性变构活化剂。Danicamtiv 增加心脏的收缩功能并保持机械效率。
货号:ajcx29254
CAS:1970972-74-7
分子式:C16H20F3N5O4S
分子量：435.42
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Danicamtiv, an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency[1].

[1]. Sarah Fernandes, et al. Abstract 15707: MYK-491, a Novel Small-Molecule Cardiac Myosin Activator Increases Cardiac Systolic Function and Preserves Mechanical Efficiency: Pre-Clinical in vivo and in vitro Evidence. Circulation. 2019;140:A15707 [2]. Johan Oslob, et al. 4-methylsulfonyl-substituted piperidine urea compounds for the treatment of dilated cardiomyopathy (dcm). WO2016118774A1.