LC3-mHTT-IN-AN2 (Compound AN2) 是一种 mHTT-LC3 连接化合物，LC3-mHTT-IN-AN2 与突变型亨廷顿蛋白 (mHTT) 和 LC3B 相互作用，但不与 wtHTT 或无关的对照蛋白相互作用。LC3-mHTT-IN-AN2 以等位基因选择性的方式降低了亨廷顿病 (HD) 小鼠神经元中mHTT水平。
货号:ajcx16400
CAS:7758-73-8
分子式:C15H10O4
分子量：254.24
溶解度:DMSO: 250 mg/mL (983.32 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

LC3-mHTT-IN-AN2 (Compound AN2) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons[1].

[1]. Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Oct 30.