WJ460 是一种有效的肌成纤维蛋白 (MYOF) 抑制剂，可与 MYOF 直接相互作用，并在乳腺癌细胞的纳摩尔范围内发挥抗转移活性。
货号:ajcx14454
CAS:1415251-36-3
分子式:C27H28N2O3S
分子量：460.59
溶解度:DMSO: 250 mg/mL (542.78 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

WJ460 is a potent myoferlin (MYOF) inhibitor, which interacts directly with MYOF and exerts anti-metastatic activity in the nanomolar range in breast cancer cells[1].

WJ460 blocks breast cancer cell invasion with IC50 values of 43.37 ± 3.42 nM in MDA-MB-231 and 36.40 ± 4.51 nM in BT549 cells. WJ460 treatment remarkably inhibits MDA-MB-231 and BT549 cell invasion through Collagen I in a dose-dependent manner[1].

WJ460 inhibits breast tumor growth, angiogenesis, and spontaneous metastasis in a spontaneous metastasis model[1].

[1]. Zhang T, et al. A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer. Nat Commun. 2018 Sep 13;9(1):3726.