GSK2983559 free acid (compound 3) 是一种高效、特异性的，口服有效的受体相互作用蛋白 2 (RIP2) 激酶抑制剂。GSK2983559 free acid 在体内和人类炎症性肠病外植体样本中，具有良好的阻断多种促炎细胞因子反应活性。
货号:ajcx14220
CAS:1579965-12-0
分子式:C21H23N4O7PS2
分子量：538.53
溶解度:DMSO: 5 mg/mL (9.28 mM; ultrasonic and warming and heat to 80°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

GSK2983559 free acid (compound 3) is a potent, specific and oral bioavailable receptor interacting protein 2 (RIP2) kinase inhibitor. GSK2983559 free acid has excellent activity in blocking many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples[1].

[1]. Haile PA, et al. Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases. J Med Chem. 2019 Jul 25;62(14):6482-6494.