Larixyl acetate 是一种有效的选择性 TRPC6 抑制剂，对 hTRPC6-YFP 和 hTRPC3-YFP 的 IC50 值分别为 0.58 μM 和 6.83 μM。
货号:ajcx26154
CAS:4608-49-5
分子式:C22H36O3
分子量：348.5
溶解度:Chloroform: slightly soluble,Ethyl Acetate: slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Larixyl acetate is a diterpenoid that has been found inLarixand has transient receptor potential canonical 6 (TRPC6) inhibitory and analgesic activities.^1,2It inhibits the activity of TRPC6 (IC₅₀= 0.58 µM) and is selective for TRPC6 over TRPC3 (IC₅₀= 6.83 µM), as well as over nine additional TRP channels at 10 µM.¹Intrathecal administration of larixyl acetate reduces mechanical and cold allodynia in a rat model of neuropathic pain induced by spared nerve injury (SNI).

1.Urban, N., Wang, L., Kwiek, S., et al.Identification and validation of larixyl acetate as a potent TRPC6 inhibitorMol. Pharmacol.89(1)197-213(2016) 2.Wang, J., Zhao, M., Jia, P., et al.The analgesic action of larixyl acetate, a potent TRPC6 inhibitor, in rat neuropathic pain model induced by spared nerve injuryJ. Neuroinflammation17(1)118(2020)