PYD-106 是一种立体选择性吡咯烷酮 (PYD) 正向变构调节剂，用于含有 GluN2C 的 NMDA 受体。
货号:ajcx23374
CAS:1560894-05-4
分子式:C25H24N2O5
分子量：432.5
溶解度:DMSO: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PYD-106 is a positive allosteric modulator of NR2C subunit-containing NMDA receptors (NMDARs).¹It enhances glutamate-induced maximal current responses in HEK293 cells expressing NR1/NR2C NMDA receptors (EC₅₀= 13 µM). PYD-106 is selective for NR2C subunit-containing NMDA receptors over NRA-, NR2B-, and NR2D-subunit containing NMDA receptors inXenopusoocytes expressing NR1/NR2 heteromeric NMDA receptors at 30 µM.

1.Khatri, A., Burger, P.B., Swanger, S.A., et al.Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulatorMol. Pharmacol.86(5)548-560(2014)