FR-190809是一种有效、可口服、无肾上腺毒性的酰基辅酶A-胆固醇酰基转移酶(ACAT)抑制剂，IC50值为45nM。
货号:ajcx12598
CAS:215589-63-2
分子式:C29H34FN3O6S2
分子量：603.73
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

FR-190809 is a potent, nonadrenotoxic, orally efficacious acyl-CoA:cholesterol O-acyltransferase (ACAT) inhibitor, with an IC50 of 45 nM[1].

FR-190809 inhibits foam cell formation with an IC50 of 215 nM[1].

[1]. Tanaka A, et al. Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 3. Discovery of a novel series of N-alkyl-N-[(fluorophenoxy)benzyl]-N'-arylureas with weak toxicological effects on adrenal glands. J Med Chem. 1998 Oct 22;41(22):4408-20.