Norbergenin

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Norbergenin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

规格:	98%
分子量:	314.246

包装与价格：

包装	价格(元)
5mg	询价
25mg	询价

Norbergenin 是 bergenin 的 O-去甲基衍生物，具有中等的抗氧化活性（在 DPPH 自由基清除中 IC50 为 13 μM；在超氧阴离子清除中为 32 μM）。
货号:ajcx12012
CAS:79595-97-4
分子式:C13H14O9
分子量：314.246
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Norbergenin, an O-demethylated derivative of bergenin, can be isolated from rhizomes of Bergenia stacheyi.

Norbergenin shows anti-arthritic activity through modulation of Th1/Th2 cytokine balance, and it inhibits the production of proinflammatory Th1 cytokines (IL-2, IFN-γ and TNF-α) while as potentiate anti-inflammatory Th2 cytokines (IL-4 and IL-5) in the peripheral blood of adjuvant-induced arthritic balb/c mice.[1]

Norbergenin inhibits bovine adrenal tyrosine hydroxylase (TH) activity by 29.0% and 53.4% at a concentration of 20 μg/mL, and exhibited noncompetitive inhibition of TH activity with the substrate L-tyrosine. [2]

Norbergenin shows moderate antioxidant activity (IC50 13 μM in DPPH radical scavenging; 32 μM in superoxide anion scavenging). [3]

参考文献:
[[1] Nazir N, et al. J Ethnopharmacol. 2007 Jun 13;112(2):401-5.
[2] Zhang YH, et al. Phytother. Res. 2003 Sep;17(8):967-9.
[3] Takahashi H, et al. Bioorg. Med. Chem. 2003 Apr 17;11(8):1781-8.

Protocol:

Kinase experiment [1]:
	Inhibition of TH activity: Norbergenin inhibits the bovine adrenal TH activity by 51.0% at 5 μg/mL, 51.6% at 10 μg/mL, 53.4% at 20 μg/mL, respectively.
Cell experiment [2]:
Cell lines	Neuronal cells (Rat)
Preparation method	The solubility of this compound in DMSO is > 1 mM..
Reaction Conditions	3 days
Applications	Norbergenin can enhance antioxidant activity, which can be further related to protecting neurons from damage by ROS
Animal experiment [3]:
Animal models	balb/c mice
Dosage form	5, 10, 20, 40 and 80 mg/kg per oral dose
Applications	Norbergenin inhibit Th1 (IL-2, IFN-γ and TNF-α) and up-regulates Th2 cytokines (IL-4 and IL-5) significantly, and release the symptom of oedema at 40 and 80 mg/kg.
Other notes	Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.
参考文献: [1] Nazir N, et al.J Ethnopharmacol. 2007 Jun 13;112(2):401-5. [2] Zhang YH, et al.Phytother. Res. 2003 Sep;17(8):967-9. [3] Takahashi H, et al.Bioorg. Med. Chem. 2003 Apr 17;11(8):1781-8.