MS7972 是一种阻断人 p53 和 CREB 结合的小分子。MS7972 在50 μM 的时候几乎可以完全阻断 BRD 的相互作用。
货号:ajcx33492
CAS:352553-42-5
分子式:C14H13NO2
分子量：227.26
溶解度:DMSO : 100 mg/mL (440.02 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

MS7972 is a small molecule that blocks human p53 and CREB binding protein association. MS7972 can almost completely block this BRD interaction at 50 μM[1].

Addition of MS7972 to the CBP BRD results in emission at 445 nm and quenching of the CBP BRD due to resonance energy transfer[1].

[1]. Sachchidanand, et al. Target structure-based discovery of small molecules that block human p53 and CREB binding protein association. Chem Biol. 2006 Jan;13(1):81-90.