CD532 hydrochloride 是一种有效的 Aurora A 激酶抑制剂，IC50 值为 45 nM。CD532 hydrochloride 具有阻断 Aurora A 激酶活性和驱动 MYCN 降解的双重作用。CD532 hydrochloride 还可以直接与 AURKA 相互作用并诱导整体构象转变。CD532 hydrochloride 可用于癌症的研究。
货号:ajcx33230
CAS:N/A
分子式:C26H26ClF3N8O
分子量：558.99
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CD532 hydrochloride is a potent Aurora A kinase inhibitor with an IC50 of 45 nM. CD532 hydrochloride has the dual effect of blocking Aurora A kinase activity and driving degradation of MYCN. CD532 hydrochloride also can directly interact with AURKA and induces a global conformational shift. CD532 hydrochloride can be used for the research of cancer[1][2].

[1]. Gustafson WC, et, al. Drugging MYCN through an allosteric transition in Aurora kinase A. Cancer Cell. 2014 Sep 8;26(3):414-427.
[2]. Lee JK, et, al. N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. Cancer Cell. 2016 Apr 11;29(4):536-547.