CBR-470-2

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CBR-470-2

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

规格:	98%
分子量:	402.27

包装与价格：

包装	价格(元)
5mg	询价
10mg	询价
25mg	询价
50mg	询价
100mg	询价

CBR-470-2是甘氨酸取代的类似物，可以激活NRF2信号传导。CBR-470-2可用于调节糖酵解。
货号:ajcx32154
CAS:2416095-00-4
分子式:C12H13Cl2NO6S2
分子量：402.27
溶解度:DMSO: 200 mg/mL (497.18 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CBR-470-2, a glycine-substituted analog, can activate NRF2 signaling. CBR-470-2 can be used for the research of modulation glycolysis[1].

CBR-470-2 (1-10 μM; 24 h) increases transcript levels of the NRF2-responsive genes NQO1 and HMOX1 in epidermal keratinocytes and dermal fibroblasts[1].

CBR-470-2 (50 mg/kg; p.o. twice daily for 10 d) induces activation of NRF2 signaling in vivo[1]. Animal Model: Balb/C mice (5-week old) are exposed to UVB[1]

[1]. Bollong MJ, et, al. A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. Nature. 2018 Oct;562(7728):600-604.