PKUMDL-LC-101-D04 (GPX4-Activator-1d4) 是一种有效的铁死亡调节剂谷胱甘肽过氧化物酶 4 (GPX4) 变构激活剂 (pEC50=4.7)。
货号:ajcx20136
CAS:2143896-83-5
分子式:C14H22N4O2S2.HCl
分子量：378.9
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PKUMDL-LC-101-D04 is an allosteric activator of glutathione peroxidase 4 (GPX4).1 It increases GPX4 activity to 150% of control levels when used at a concentration of 20 μM in a cell-free assay and at 61 μM in wild-type, but not Gpx4-/-, mouse embryonic fibroblast (MEF) extracts. PKUMDL-LC-101-D04 (200 μM) also reduces cholesterol hydroperoxide-induced MEF death.

|1. Li, C., Deng, X., Zhang, W., et al. Novel allosteric activators for ferroptosis regulator glutathione peroxidase 4. J. Med. Chem. 62(1), 266-275 (2019).