PAR3(1-6)amide(human)(trifluoroacetate salt)

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包装:	5mg
规格:	98%
市场价:	6653元
分子量:	646.7

C29H46N10O7.XCF3COOH
货号:ajcx19572
CAS:N/A
分子式:C29H46N10O7.XCF3COOH
分子量：646.7
溶解度:Water: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PAR3 (1-6) amide is a synthetic peptide agonist of proteinase-activated receptor 1 (PAR1) and PAR2 that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR3 and residues 39-44 of the full-length human sequence. PAR3 (1-6) amide activates PAR1 and PAR2 in Jurkat and HEK cells, inducing calcium accumulation in Jurkat cells, which is reduced following desensitization with the PAR1- and PAR2-selective peptide agonist SFLLR-NH2.1 It decreases the expression of CDC42 in wild-type, but not PAR3 knockdown, PANC-1 cells and reduces invasion of PANC-1 cells.2

参考文献
1. Hansen, K.K., Saifeddine, M., and Hollenberg, M.D. Tethered ligand-derived peptides of proteinase-activated receptor 3 (PAR3) activate PAR1 and PAR2 in Jurkat T cells. Immunology 112(2), 183-190 (2004).
2. Segal, L., Katz, L.S., Lupu-Meiri, M., et al. Proteinase-activated receptors differentially modulate in vitro invasion of human pancreatic adenocarcinoma PANC-1 cells in correlation with changes in the expression of CDC42 protein. Pancreas 43(1), 103-108 (2014).